Close
Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Search
ACE Inhibitors

ACE Inhibitors (Paperback)

£72.00
Printed to order. Despatched in 2-3 weeks.
Email me when back in stock

Synopsis

Angiotensin converting enzyme inhibitors (ACEI) represent the first class of antihypertensive agents that was designed and developed on the basis of a well-defined physiopathological axis of arterial hypertension, a vascular dis- order that is now becoming one of the major causes of morbidity/mortality, not only in developed societies but also in the highly populated developing coun- tries [1]. CAPTOPRIL, the prototype of the "PRIL" family, which now comprises more than 40 molecule-species, was quite hazardous and the clinical develop- ment almost failed when serious side-effects were reported in an alarmist fash- ion in reputable scientific journals, such as the New England Journal of Medicine and Lancet. Squibb & Sons came very close to withdrawing CAPTOPRIL from clinical investigation [2]. However, after re-examination of the data obtained from different categories of patients and appropriate dose-adjustments, the clinical use of CAPTOPRIL turned out to be revolutionary. The prototype, as well as other members of the "PRIL" family became the starting point for numerous basic and clinical research programs, focusing on the interactions of ACEI with the kinin, endothelin, and nitric oxide systems, and the contribution of the receptors for AT I, AT 2, bradykinin Bland B , ETA and ET B to the pharmacological actions 2 of the respective peptides. This research activity led to the development of new pharmacological agents, such as the angiotensin receptor antagonists and, more recently, the neutral endopeptidase inhibitors. In the near future, bradykinin receptor antagonists also will be available to modulate ACEI phar- macological actions.

Home & GardenGardeningMedical & VeterinaryMedicine: general issues Publisher: Springer Basel Publication Date: 01/11/2001 ISBN-13: 9783034875813  Details: Type: Paperback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

More books by Pedro D'Orleans-Juste

More books by G. E. Plante

Leave Review

Delivery

Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Standard Delivery FREE FREE 3-5 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Urban Gardening as Politics
(Hardback)
Chiara Tornaghi; Chiara Certoma
 
 
£95.00
 
Specifying Ambient Worlds:...
(Hardback)
Thomas Mical
 
 
£115.00
 
The Crocus King: E.A. Bowles of...
(Paperback)
Bryan Hewitt
 
 
£9.99
 
Exotic Fruits Reference Guide
(Hardback)
Sueli Rodrigues
 
 
£160.00
 
Latest Blog
Johann Hari Takes Issue with the Concept of Self-Help
18/01/2018

Johann Hari explains why, in order to feel better, we must stop being 'you', in favour of being 'us', being 'we', becoming part of the group.

Jealousy, Rivalry, Insecurity, Frustration... Non Pratt Explores the World of Female Teenage Friendships
16/01/2018

Non explores friendship in YA novels and especially those that depict the imperfect middle ground.

#FoylesFive: Pre-orders
15/01/2018

Matt from our Web Team jumps into the future and brings back some reading recommends for 2018.

View all Blog Entries
Twitter
Show/Hide Tweets
© W&G Foyle Ltd