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B Cell Receptor Signaling

B Cell Receptor Signaling (Hardback)

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volume details our current understanding of the architecture and signaling

capabilities of the B cell antigen receptor (BCR) in health and disease. The

first chapters review new insights into the assembly of BCR components and

their organization on the cell surface. Subsequent contributions focus on the

molecular interactions that connect the BCR with major intracellular signaling

pathways such as Ca2+ mobilization, membrane phospholipid

metabolism, nuclear translocation of NF-kB or

the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements

orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics

for antigen internalization. Furthermore, a key mechanism of how B cells

remember their cognate antigen is discussed in detail. Altogether, the discoveries

presented provide a better understanding of B cell biology and help to explain

some B cell-mediated pathogenicities, like autoimmune phenomena or the

formation of B cell tumors, while also paving the way for eventually combating these


Medical & VeterinaryBrances of medicineDiseases & disordersImmunologyMedical & VeterinaryBrances of medicineDiseases & disordersOncologyMedical & VeterinaryMedicine: general issuesMedical equipment & techniquesMedical research Publisher: Springer International Publishing AG Publication Date: 26/12/2015 ISBN-13: 9783319261317  Details: Type: Hardback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jurgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Gottingen, Germany

More books by Tomohiro Kurosaki

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