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Clinical Trials of Antidepressants: How Changing the Model Can Uncover New, More Effective Molecules

Clinical Trials of Antidepressants: How Changing the Model Can Uncover New, More Effective Molecules (Paperback)

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This brief guide takes current clinical trial protocols to

task and replaces them with a contemporary framework for improving

next-generation antidepressants and their underlying science. Innovative models

are based on a nuanced, neurologically-informed understanding of drug

mechanisms and the component cognitive, mood, and behavioral aspects of

depression. The book reconceptualizes not only the clinical trial process but

the clinical concept of depression itself as essential to bringing

pharmaceutical research and development up to date, boosting efficiency and

effectiveness, finding new molecules, and reducing waste. Case studies and a

review of salient depression scales illustrate the potential benefits of such

wide-scale change. Included in the coverage:


now the need for a new clinical trials model for antidepressants? Aims

and basic requirements of clinical trials: conventional and

component-specific models.Methods

for measuring the components and the profile of drug actions: the

multivantaged approach.Achieving

the ideal clinical trial: an example of the merged componential and

established models.Prediction

and shortening the clinical trial.The

video clinical trial.

Clinical Trials of

Antidepressants will interest a varied audience, including clinical

investigators, academic and pharmaceutical company scientists, clinical trial

organizations, psychiatrists, outpatient physicians, psychotherapists, clinical

psychologists, psychology graduate students, medical students, and government

agencies such as the FDA.

Medical & VeterinaryBrances of medicinePharmacologyPsychopharmacologyMedical & VeterinaryBrances of medicinePsychiatryMedical & VeterinaryMedicine: general issuesMedical equipment & techniquesMedical researchMedical & VeterinaryMedicine: general issuesPublic health & preventive medicinePersonal & public health Publisher: Springer International Publishing AG Publication Date: 09/02/2016 ISBN-13: 9783319264639  Details: Type: Paperback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

Martin M. Katz received his A.B. degree in Chemistry at Brooklyn College and his Ph.D. from the University of Texas in Psychology and Physiology. From 1958 to 1968, he served in the National Institute of Mental Health's (NIMH as Executive Secretary of its first Psychopharmacology Advisory Committee, then, in 1965, as Head of its Special Studies section in Psychopharmacology. In 1968 he was appointed Chief, of the Institute's Clinical Research Branch, a new program charged with expanding research on the causes and treatment of schizophrenia and the affective disorders. It initiated national conferences and developed Collaborative Programs on the Psychobiology of Depression laying the groundwork for the new DSM and large scale testing of the new biochemical theories of the genesis of the disorders. The Biology and Clinical Collaborative Programs created by Dr. Katz and Branch Staff (1970-1978), were responsible for the training of many young investigators, and provided needed methodology for expanding research in these fields. The Clinical Aspect of the Program was still, thirty years later, in operation under an NIMH grant. In 1984, he joined the Psychiatry faculty at Albert Einstein College of Medicine as Professor establishing the first Division of Psychology and Laboratory of Psychopathology at the College. Since 1996, he has been Adjunct Research Professor in the Department of Psychiatry, University of Texas Health Science Center at San Antonio, where he has conducted grant-supported research on the "Biological Aspects of Depression" and the neurobehavioral mechanisms of action of antidepressant drugs.

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