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Connections, Cognition, and Alzheimer's Disease

Connections, Cognition, and Alzheimer's Disease (Hardback)

£72.00
Unavailable. This title is Out of Print.
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Synopsis

Alzheimer's disease invades the brain from the inside. Unlike an abcess, a metas- tasis or an infarct, the disease follows specific tracks and avoids certain cortical areas while flourishing in others. Any observer is struck by the exquisite selectiv- ity of the lesions and could, indeed, conclude that Alzheimer's disease knows neuroanatomy. However, should the term "disease" be used to define this disor- der? Several genes, located on at least three different chromosomes, have been implicated in the disease. The ApoE4 genotype has been shown to be an impor- tant risk factor, but dementia pugilistica also suggests that environment can be involved in at least some aspects of the disorder. These data favor the now preva- lent view that Alzheimer's disease should instead be considered as a syndrome, and probably all of the contributors to this volume are ready to endorse this point of view. If "Alzheimer's syndrome" is the final common pathway to several pathoge- netic mechanisms, there should be an event at one point in the course of the spe- cific etiology that triggers a somewhat stereotypic diffusion process along some neural connections.

Scientists who are fascinated by the way in which the ner- vous system has morphologically encoded its function after a long phylogenetic history are also fascinated by this pathological progression of Alzheimer's syn- drome.

Medical & VeterinaryBrances of medicineGeriatric medicineMedical & VeterinaryBrances of medicineNeurology & clinical neurophysiologyScience & MathematicsBiology, life sciencesLife sciences: general issuesNeurosciences Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Publication Date: 09/04/1997 ISBN-13: 9783540622055  Details: Type: Hardback Format: Books
Availability: Unavailable. This title is Out of Print.  

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