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Der Il-1-Rezeptor-Antagonist Im Zytokin-Netzwerk: Funktion Und Stellenwert

Der Il-1-Rezeptor-Antagonist Im Zytokin-Netzwerk: Funktion Und Stellenwert (Paperback)

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Synopsis

Die Ursachen der rheumatoiden Arthritis (RA) sind trotz intensiver Forschungsarbeiten immer noch nicht geklart. Das Wissen um die Pathogenese hat in den letzten Jahren jedoch stark zugenommen. Die Identifizierung der Regelkreise im Zytokin-Netzwerk mit den einzelnen daran beteiligten Zytokinen war der entscheidende Schritt fur die Entwicklung spezifischer Therapieformen zur Behandlung rheumatischer Erkrankungen, insbesondere der RA. Interleukin-1 (IL-1) und Tumornekrosefaktor-a (TNF-allpha) sind die beiden Schlusselzytokine im pathologischen Geschehen der RA. IL-1 ist in erster Linie fur die destruktiven Ablaufe und die Hemmung von Reparaturvorgangen an Knorpel und Knochen verantwortlich. Hier liegt der wesentliche Angriffspunkt des Interleukin-1-Rezeptor-Antagonisten (IL-1ra). Dieses Buch fasst sowohl Ergebnisse der Grundlagenforschung zur Rolle von Zytokinen bei der RA als auch klinische Erfahrungen bei der Therapie mit einem rekombinanten IL-1-Rezeptor-Antogonisten zusammen.

Medical & VeterinaryBrances of medicineDiseases & disordersMedical & VeterinaryBrances of medicineRheumatology Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Publication Date: 20/11/2013 ISBN-13: 9783642537813  Details: Type: Paperback Format: Books
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