Close
Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Search
Manufacturing of Gene Therapeutics: Methods, Processing, Regulation, and Validation

Manufacturing of Gene Therapeutics: Methods, Processing, Regulation, and Validation (Paperback)

£123.00
Printed to order. Despatched in 2-3 weeks.
Email me when back in stock

Synopsis

Advances in molecular biology and recombinant DNA technology have accelerated progress in many fields of life science research, including gene therapy. A large number of genetic engineering approaches and methods are readily available for gene cloning and therapeutic vector construction. Significant progress is being made in genomic, DNA sequencing, gene expression, gene delivery and cloning. Thus gene therapy has already shown that it holds great promise for the treatment of many diseases and disorders. In general it involves the delivery of recombinant genes or transgenes into somatic cells to replace proteins with a genetic defect or to transfer with the pathological process of an illness. The viral and non-viral delivery systems may hold the potential for future non-invasive, cost-effective oral therapy of genetically-based disorders. Recent years have seen considerable progress in the discovery and early clinical development of a variety of gene therapeutic products. The availability, validation, and implementation of gene therapeutic products has also enabled success in testing and evaluation. New challenges will need to be overcome to ensure that products will also be successful in later clinical development and ultimately for marketing authorisation. These new challenges will include improvements in delivery systems, better control of in-vivo targeting, increased level transduction and duration of expression of the gene, and manufacturing process efficiencies that enable reduction in production costs. Perhaps profound understanding of regulated gene design may result in innovative bioproducts exhibiting safety and efficacy profiles that are significantly superior to those achieved by the use of naturally occurring genes. This procedure may contribute considerably to fulfilling standards set by regulatory authorities. This book provides an overview of the current advances in the field of gene therapy and the methods that are being successfully applied in the manufacture of gene therapeutic products, and hopefully will stimulate further progress and advancement in this field to meet the ever-increasing demands.

More books by G. Subramanian

Leave Review

Delivery

Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Standard Delivery FREE FREE 3-5 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Epigenetics of Aging and Longevity:...
(Hardback)
Alexey Moskalev; Alexander M. Vaiserman
 
 
£119.00
 
Genetics: From Genes to Genomes
(Paperback)
Hartwell
 
 
£56.99
 
Epigenetic Landscapes: Drawings as...
(Paperback)
Susan Merrill Squier
 
 
£20.99
 
Functional Genomics: Novel Insights,...
(Paperback)
Holger Uffe; Olaf Philip
 
 
£78.50
 

Currently out of stock

Latest Blog
#FoylesFive: Book Friday
24/11/2017

Today's the day known as Black Friday, or Book Friday as we like to call it! To celebrate we wanted to give you money off our favourite books!

#FoylesFive: Buddhism & Meditation
23/11/2017

Stressed? Carmelo from our Charing Cross Road flagship shop has just the thing.

The Satisfaction of a Good Puzzle
21/11/2017

Alex Bellos extols the virtues of the puzzle, especially those from the great puzzle masters of Japan, and selects some of his favourite puzzle books.

View all Blog Entries
Twitter
Show/Hide Tweets
© W&G Foyle Ltd