Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Mechanisms of Lymphocyte Activation and Immune Regulation: v. 3

Mechanisms of Lymphocyte Activation and Immune Regulation: v. 3 (Hardback)

Unavailable. This title is Out of Print.
Email me when back in stock


Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest."

Medical & VeterinaryBrances of medicineDiseases & disordersImmunology Publisher: Kluwer Academic Publishers Group Publication Date: 31/07/1991 ISBN-13: 9780306439223  Details: Type: Hardback Format: Books
Availability: Unavailable. This title is Out of Print.  

More books by Sudhir Gupta

More books by etc.

Leave Review


Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Second Class Available free for ALL orders. No charge for each additional book. 3-7 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Immune: How Your Body Defends and...
Catherine A. Carver
Advances in Immunology: Volume 135
Frederick Alt
WHO Expert Committee on Biological...
World Health Organization

Currently out of stock

Bacterial Evasion of the Host Immune...
Pedro Escoll

Currently out of stock

Latest Blog
#FoylesFive: Elsewhere-Elsewhen

Jen from the Web Team shares a selection of books that will transport the reader to another time and place.

Growler: The Inspiration for the Now Iconic Bear

James Campbell describes how the groundbreaking approach to illustration adopted by Milne and Shepard came about, which bear provided the inspiration for the drawings and which of the characters was Shepard's secret favourite.

Blog - Sound and Silence: Emma Viskic on Creating a Profoundly Deaf Protagonist

In this exclusive blog Emma Viskic describes how she came to learn sign language in order to get closer to her deaf protagonist in her debut, Resurrection Bay.

View all Blog Entries
Show/Hide Tweets
© W&G Foyle Ltd