Close
Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Search
Neurodegenerative Disorders: Loss of Function Through Gain of Function

Neurodegenerative Disorders: Loss of Function Through Gain of Function (Paperback)

£132.00
Printed to order. Despatched in 2-3 weeks.
Email me when back in stock

Synopsis

Fondation Ipsen sponsored a meeting in Paris in February 2000 on the emerging paradigm-shift in our understanding of the major degenerative diseases which- affect the aging human brain. This book sumarizes our deliberations on some of these major neurodegenerative diseases that are characterized by protein depos- its, and that are due to the pathogenic gain of function of an otherwise normal neuronal protein. For each of the major human neurodegenerative diseases covered in this book -the most prominent being Alzheimer's disease -experimental models are described, including cell culture systems and animal models which range from the round worm, Caenorhabditis elegans, the fruitfly, Drosophila melanogaster, to rodents. Remarkably, in the sporadic forms of these human diseases, only a minor change in the level of production or turn-over of the relevant proteins is sufficient to cause disease in late adult-hood. Neurodegeneration in Alzheimer's disease, for example, usually results in symptoms and signs in the seventh to eighth decades.

In contrast, the development of protein deposits in transgenic mice over-expressing the corresponding disease gene parallels the genetic forms of the human diseases in regard to its manifestation occuring half-way through its normal life-span, i. e. about 50 years in humans (the so-called "presenium") and 9 to 12 months in the mouse. Nevertheless, these models have served to elu- cidate many of the pathways underlying the human disease processes, for instance clarifying the neuronal origin of parenchymal and perivascular amyloid in Alzheimer's disease and Creutzfeldt-Jakob disease.

Medical & VeterinaryBrances of medicineNeurology & clinical neurophysiologyScience & MathematicsBiology, life sciencesLife sciences: general issuesNeurosciences Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Publication Date: 06/12/2010 ISBN-13: 9783642074486  Details: Type: Paperback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

More books by Konrad Beyreuther

More books by Yves Christen

More books by Colin L. Masters

Leave Review

Delivery

Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Standard Delivery FREE FREE 3-5 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

The Confabulating Mind: How the Brain...
(Paperback)
Armin Schnider
 
 
£27.99
 
Explanation and Integration in Mind...
(Hardback)
David M. Kaplan
 
 
£45.00
 
Know Thyself: The Value and Limits of...
(Paperback)
Mitchell S. Green
 
 
£14.99
 
Latest Blog
Why Little Women is the Perfect Christmas Read
15/12/2017

Publisher of the Macmillan Collectors Library, Harriet Sanders, celebrates the arrival on tv this Christmas of Little Women

#FoylesFive: Foreign Languages Part Two
13/12/2017

Our knowledgeable Languages Department have put together a great selection of books, to help share the magic of reading in every language. Here are their Dutch, Russian and Polish selections.

#FoylesFive: The Last Jedi
12/12/2017

As Star Wars: The Last Jedi drops out of hyperspace and into a cinema near you, Matt from our Web Team gives us his selection of the best Last Jedi books.

View all Blog Entries
Twitter
Show/Hide Tweets
© W&G Foyle Ltd