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NF-κB-Related Genetic Diseases

NF-κB-Related Genetic Diseases (Paperback)

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Synopsis

This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

Medical & VeterinaryMedicine: general issuesMedical equipment & techniquesMedical researchMedical & VeterinaryPre-clinical medicine: basic sciencesMedical geneticsScience & MathematicsBiology, life sciencesBiochemistry Publisher: Springer International Publishing AG Publication Date: 30/12/2015 ISBN-13: 9783319258485  Details: Type: Paperback Format: Books
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Gilles Courtois (INSERM) and colleagues are performing genetic research at the Institut des Neurosciences de Grenoble. They have demonstrated details of the NF-kB signaling pathway and collaborate on publications about Incontinentia Pigmenti, a genetic disease of the skin, hair, teeth and central nervous system. He and his team are working with the group of Annie Andrieux and Eric Denarier on mice lacking the NEMO protein, one component of the signal cascade, exclusively in their nervous system or throughout their body. The studies focus on neurological problems but will provide insight into the signaling pathway from different angles.

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