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Peptide and Protein Drug Analysis

Peptide and Protein Drug Analysis (Hardback)

£153.00
Printed to order. Despatched in 2-3 weeks.
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Synopsis

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication.

Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis * discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability * analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology * examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods * highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry * demonstrates uses of unnatural mutagenesis and combinatorial chemistry * explores mass spectrometry, protein sequence, and carbohydrate analysis * illustrates bioassays and other new functional analysis methods * surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) * addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells * reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering * and more!

Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.

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