Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
DNA Methylation, Epigenetics and Metastasis

DNA Methylation, Epigenetics and Metastasis (Hardback)

Usually despatched within 2 weeks.
Order now for Free delivery in the UK.
More on delivery...


Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors "conspire" to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them.

In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is now the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio.

Science & MathematicsBiology, life sciencesMolecular biology Publisher: Springer-Verlag New York Inc. Publication Date: 09/06/2005 ISBN-13: 9781402036415  Details: Type: Hardback Format: Books
Availability: Usually despatched within 2 weeks. Login for Quick Checkout Add to Basket

More books by Manel Esteller

Leave Review


Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Standard Delivery FREE FREE 3-5 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Gangliosides in Health and Disease:...
Ronald L Schnaar; Pablo H.H. Lopez
Bench to Bedside: Diagnostic...
Nancy Khardori
MicroRNA: Perspectives in Health and...
Jaishree Paul; Rohini Muthuswami
The Rise of Yeast: How the sugar...
Nicholas P. Money
Latest Blog
On Memory and Forgetting

David Whitehouse talks to us about memory and forgetting, and how his personal experience influenced his new novel, The Long Forgotten.

The End of the F***ing World creator, Charles Forsman, picks his favourite coming of age books

The End of the F***ing World creator, Charles Forsman, picks his favourite coming of age books.

#FoylesFive: Annihilation

With the release of Annihilation on Netflix it's the perfect time to catch up with the book that starts Jeff VanderMeer's unsettling Southern Reach trilogy.

View all Blog Entries
Show/Hide Tweets
© W&G Foyle Ltd