Close
Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Search
Neurodegenerative Disorders: Loss of Function Through Gain of Function

Neurodegenerative Disorders: Loss of Function Through Gain of Function (Paperback)

£123.00
Printed to order. Despatched in 2-3 weeks.
Email me when back in stock

Synopsis

Fondation Ipsen sponsored a meeting in Paris in February 2000 on the emerging paradigm-shift in our understanding of the major degenerative diseases which- affect the aging human brain. This book sumarizes our deliberations on some of these major neurodegenerative diseases that are characterized by protein depos- its, and that are due to the pathogenic gain of function of an otherwise normal neuronal protein. For each of the major human neurodegenerative diseases covered in this book -the most prominent being Alzheimer's disease -experimental models are described, including cell culture systems and animal models which range from the round worm, Caenorhabditis elegans, the fruitfly, Drosophila melanogaster, to rodents. Remarkably, in the sporadic forms of these human diseases, only a minor change in the level of production or turn-over of the relevant proteins is sufficient to cause disease in late adult-hood. Neurodegeneration in Alzheimer's disease, for example, usually results in symptoms and signs in the seventh to eighth decades.

In contrast, the development of protein deposits in transgenic mice over-expressing the corresponding disease gene parallels the genetic forms of the human diseases in regard to its manifestation occuring half-way through its normal life-span, i. e. about 50 years in humans (the so-called "presenium") and 9 to 12 months in the mouse. Nevertheless, these models have served to elu- cidate many of the pathways underlying the human disease processes, for instance clarifying the neuronal origin of parenchymal and perivascular amyloid in Alzheimer's disease and Creutzfeldt-Jakob disease.

Medical & VeterinaryBrances of medicineNeurology & clinical neurophysiologyScience & MathematicsBiology, life sciencesLife sciences: general issuesNeurosciences Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Publication Date: 06/12/2010 ISBN-13: 9783642074486  Details: Type: Paperback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

More books by Konrad Beyreuther

More books by Yves Christen

More books by Colin L. Masters

Leave Review

Delivery

Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Second Class Available free for ALL orders. No charge for each additional book. 3-7 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Waking the Spirit: A Musician's...
(Paperback)
Andrew Schulman
 
 
£12.99
 
Executive Function: Development ...
(Paperback)
Sandra A. Wiebe; Julia Karbach
 
 
£31.99
 
Fundamentals of Laboratory Animal...
(Hardback)
Enqi Liu; Jianglin Fan
 
 
£69.99
 
Noradrenergic Signaling and Astroglia
(Hardback)
Nina Vardjan; Robert Zorec
 
 
£78.95
 
Latest Blog
ZED Books: The role of the independent publisher in a content-obsessed world
18/08/2017

Indie publisher ZED Books have a radical approach to their books and their company structure. Here, they talk to us about the role independent publishers can play in a world of ever expanding (and less than reliable) information sources.

Blog - J R Wallis on Monsters as Metaphors
16/08/2017

J R Wallis questions the conventional view of monsters as metaphors for the worries we have about the state of the world around us.

#FoylesFive: Creative Women
14/08/2017

Meg from the Web Team tells us why she loves to learn about creative, dynamic women.

View all Blog Entries
Twitter
Show/Hide Tweets
© W&G Foyle Ltd