Close
Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Search
Purine Metabolism in Man-II: Physiology, Pharmacology, and Clinical Aspects

Purine Metabolism in Man-II: Physiology, Pharmacology, and Clinical Aspects (Paperback)

£64.99
Printed to order. Despatched in 2-3 weeks.
Email me when back in stock

Synopsis

The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho- ribosyl transferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.

Medical & VeterinaryBrances of medicinePharmacologyScience & MathematicsBiology, life sciencesBiochemistry Publisher: Springer-Verlag New York Inc. Publication Date: 01/03/1977 ISBN-13: 9781468432879  Details: Type: Paperback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

More books by Mathias M. Muller

Leave Review

Delivery

Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Second Class Available free for ALL orders. No charge for each additional book. 3-7 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Research in the Biomedical Sciences:...
(Paperback)
Michael Williams; Michael Curtis;...
 
 
£55.95
 
Focus on Aflatoxins Research
(Paperback)
Peder Jan; Sten Sylvester
 
 
£90.50
 

Currently out of stock

Medicinal Plants for Holistic Health...
(Paperback)
Namrita Lall
 
 
£78.95
 
BNF 74 (British National Formulary)...
(Paperback)
Joint Formulary Committee
 
 
£55.00
 
Latest Blog
#FoylesFive: Picture Books for Black History Month
20/10/2017

Our Birmingham shop is celebrating Black History Month with an array of new and exciting picture books for children.

Caroline Taggart on Why Punctuation Can be Surprisingly Exciting
18/10/2017

Caroline Taggart explains the versatility of punctuation.

Under the Knife: Recreating the Grimy World of Victorian Surgery
17/10/2017

Lindsey describes how she made the trailer for her debut The Butchering Art in order to see how the sights, sounds, and smells of this gruesome period in medical history would translate onto the screen.

View all Blog Entries
Twitter
Show/Hide Tweets
© W&G Foyle Ltd