Close
Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Search
Reducing, Refining and Replacing the Use of Animals in Toxicity Testing

Reducing, Refining and Replacing the Use of Animals in Toxicity Testing (Hardback)

£159.99
To Order. Estimated despatch in 1-3 weeks.
Email me when back in stock

Synopsis

Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance.

It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.

Science & MathematicsBiology, life sciencesBiochemistryToxicology non-medical Publisher: Royal Society of Chemistry Publication Date: 31/10/2013 ISBN-13: 9781849736527  Details: Type: Hardback Format: Books
Availability: To Order. Estimated despatch in 1-3 weeks.  

David G. Allen has over 10 years experience in molecular and cellular biology. This includes the evaluation of toxicological and pharmacological data for the Food and Drug Administration (FDA), and the identification and validation of alternative toxicological assays that reduce or replace animal usage in regulatory safety testing. He received is BSc and PhD from North Carolina State University in Raleigh, and his MSc from the University of North Carolina in Wilmington. Dr Allen is currently Director of the Environmental and Regulatory Sciences Division of Integrated Laboratory Systems in North Carolina. This involves responsibility for the evaluation of alternative toxicological methods and comprehensive environmental services for the Environmental Protection Agency and the State of Georgia. The role includes all aspects of divisional management such as staffing, budget projections, and business development.

More books by Dave Allen

More books by Mike Waters

More books by Mike Waters

More books by Martin Stephens

More books by John R. Fowle

More books by Darrell R. Boverhof

More books by Jonathan

Leave Review

Delivery

Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Second Class Available free for ALL orders. No charge for each additional book. 3-7 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Nonclinical Drug Administration:...
(Hardback)
Shayne C. Gad
 
 
£108.00
 
Heavy Metals and Other Pollutants in...
(Hardback)
Gennady E. Zaikov; Larissa I....
 
 
£95.00
 
Ecotoxicology and Genotoxicology:...
(Hardback)
Michael D. Waters; Tim Marrs; Diana...
 
 
£199.00
 
Ecotoxicology and Genotoxicology:...
(Hardback)
Michael D. Waters; Tim Marrs; Diana...
 
 
£199.00
 
Latest Blog
Blog - J R Wallis on Monsters as Metaphors
16/08/2017

J R Wallis questions the conventional view of monsters as metaphors for the worries we have about the state of the world around us.

#FoylesFive: Creative Women
14/08/2017

Meg from the Web Team tells us why she loves to learn about creative, dynamic women.

Blog - What are the Books Teachers Never Tire of Teaching?
14/08/2017

The Secret Teacher talks about the books that keep on giving year after year.

View all Blog Entries
Twitter
Show/Hide Tweets
© W&G Foyle Ltd