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Targeted Therapy of Acute Myeloid Leukemia

Targeted Therapy of Acute Myeloid Leukemia (Hardback)

£162.00
Printed to order. Despatched in 2-3 weeks.
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Synopsis

This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.

Medical & VeterinaryBrances of medicineDiseases & disordersOncologyMedical & VeterinaryBrances of medicineHaematology Publisher: Springer-Verlag New York Inc. Publication Date: 21/11/2014 ISBN-13: 9781493913923  Details: Type: Hardback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

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Location 1st Book Each additional book Average Delivery Time
UK Second Class Available free for ALL orders. No charge for each additional book. 3-7 Days
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