Close
Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Search
The Sodium-Hydrogen Exchanger: From Molecule to its Role in Disease

The Sodium-Hydrogen Exchanger: From Molecule to its Role in Disease (Hardback)

£138.00
Printed to order. Despatched in 2-3 weeks.
Email me when back in stock

Synopsis

I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and Malignancy". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I succeeded in isolating mutant fibroblasts lacking the amiloride-sensitive Na+ transporter. ''Good luck!" was his response.

Science & MathematicsBiology, life sciencesCellular biology or cytologyScience & MathematicsBiology, life sciencesMolecular biology Publisher: Springer-Verlag New York Inc. Publication Date: 01/05/2003 ISBN-13: 9781402074745  Details: Type: Hardback Format: Books
Availability: Printed to order. Despatched in 2-3 weeks.  

More books by Morris Karmazyn

More books by Metin Avkiran

More books by Larry Fliegel

Leave Review

Delivery

Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
UK Second Class Available free for ALL orders. No charge for each additional book. 3-7 Days
UK First Class £4.50 £1.00 1-2 Days
UK Courier £7.00 £1.00 1-2 Days
Western Europe** Courier £17.00 £3.00 2-3 Days
Western Europe** Airmail £5.00 £1.50 4-14 Days
USA / Canada Courier £20.00 £3.00 2-4 Days
USA / Canada Airmail £7.00 £3.00 4-14 Days
Rest of World Courier £22.50 £3.00 3-6 Days
Rest of World Airmail £8.00 £3.00 7-21 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Delivery Help & FAQs

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

Measurement and Analysis of Kinetic...
(Hardback)
Michael E. Harris; Vernon Anderson
 
 
£121.00
 
Fe-S Cluster Enzymes Part A: Volume 595
(Hardback)
Sheila S. David
 
 
£121.00
 
Enterococci & Bacterial Diseases: ...
(Paperback)
Cary G Henderson
 
 
£78.50
 
Methods in Tau Cell Biology: Volume 141
(Hardback)
Stuart Feinstein; Nichole Lapointe
 
 
£104.00
 
Latest Blog
Read an Extract from A Skinful of Shadows
21/09/2017

Read an extract from the eagerly awaited new novel by the Costa-winning Frances Hardinge, A Skinful of Shadows.

#FoylesFive: Elsewhere-Elsewhen
18/09/2017

Jen from the Web Team shares a selection of books that will transport the reader to another time and place.

Growler: The Inspiration for the Now Iconic Bear
18/09/2017

James Campbell describes how the groundbreaking approach to illustration adopted by Milne and Shepard came about, which bear provided the inspiration for the drawings and which of the characters was Shepard's secret favourite.

View all Blog Entries
Twitter
Show/Hide Tweets
© W&G Foyle Ltd