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Vesicle Trafficking in Cancer
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Vesicle Trafficking in Cancer (Hardback)

£179.99
Usually despatched within 2 weeks.

Synopsis

Endocytosis and vesicular trafficking determine the landscape of the cell's exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

Medical & VeterinaryBrances of medicineDiseases & disordersOncologyScience & MathematicsBiology, life sciencesCellular biology or cytology Publisher: Springer-Verlag New York Inc. Publication Date: 03/04/2013 ISBN-13: 9781461465270  Details: Type: Hardback Format: Books
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