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Alternative Mechanisms of Multidrug Resistance in Cancer
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Alternative Mechanisms of Multidrug Resistance in Cancer (Hardback)

£68.00
Unavailable. Replaced by new product or edition.
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Synopsis

Drug resistance, whatever its source, is the prevalent cause for treatment failure in cancer chemotherapy. At present, the best understood (and most publicized) mechanism of cell resistance is the P-glycoprotein mediated efflux pump. However, it is not the only - or even the most effective - tool of survival devices to be considered in this book. Alterations of topoisomerases and conjugases, glutathione transferases, protein kinase C, the multidrug resistance protein MRP, bc12 and other modes of action are considered as well. By identifying and understanding how multidrug resistance in cancer evolves and functions, we should be able to prevent, circumvent or reverse this so far inescapable phenomenon. Featuring a collection of reviews by scientists, this book attempts to achieve an understanding of the molecular basis for drug resistance. It is intended for researchers in such diverse fields as chemotherapy, drug delivery, oncology, pathology, pharmacokinetics, tumour biology and biological response modifiers.

Medical & VeterinaryBrances of medicineDiseases & disordersOncologyMedical & VeterinaryBrances of medicinePharmacologyMedical & VeterinaryMedicine: general issuesMedical equipment & techniquesMedical research Publisher: Birkhauser Verlag AG Publication Date: 01/03/1995 ISBN-13: 9783764337759  Details: Type: Hardback Format: Books
Availability: Unavailable. Replaced by new product or edition.  

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