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Synopsis

"Der wichtigste Schritt in der Fortentwicklung aller Naturwissenschaften ist mit der Einfuhrung der Messung von Grossen gemacht worden. " (J. C. MAXWELL, Theorie der Warme, Dt. uber- setzung nach der 4. Aufl. , 1877) Die Analyse des Elektrolyt- und Wasserhaushaltes bei Patienten mit generali- sierten Odemen hat ergeben, dass die Unfahigkeit des Organismus, die mit der Nahrung zugefuhrten Natriumionen quantitativ zu eliminieren, ein gemeinsames Merkmal dieser Erkrankungen ist. Die Ansammlung von Wasser im extracellularen Raum ist lediglich die Folge dieser Natriumretention. Der Anteil der Niere an der Entstehung solcher Storungen des Elektrolyt- und Wasserhaushalts beruht auf der I mbalance glomerular-tubularer Funktionen, die renale und extrarenale Ursachen haben kann. Die Minderung der glomerularen Filtration ist fur die Entstehung der Odeme sicher von geringerer Bedeutung als die zu intensive Ruckgewinnung des Primarharns unter den pathologischen Bedingungen, die den Ausgleich der gestorten Salz- und Wasserbilanz verhindert.

Prinzipiell kann eine Vermehrung der Harnausscheidung sowohl durch Ver- grosserung der glomerularen Filtration als auch durch Hemmung der tubularen Ruckgewinnung des Primarharns erreicht werden. Die heute gebrauchlichen Diuretica verandern ganz uberwiegend tubulare Funktionen und beeinflussen daher den an zweiter Stelle genannten Prozess.

Medical & VeterinaryMedicine: general issuesMedical & VeterinaryNursing & ancillary servicesPharmacy / dispensing Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Publication Date: 04/09/2012 ISBN-13: 9783662009123  Details: Type: Paperback Format: Books
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