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Fibroblast Growth Factor 23
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Fibroblast Growth Factor 23 (Paperback)

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Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. This reference then defines the exciting research in recent years how a much wider spectrum of sources, targets and functions have been identified, showing that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues.

This reference reaches a wide academic audience with a broad interest in biomedical sciences, including:

Endocrinology: FGF23 initially identified as a bone-derived factor targeting the kidney

Physiology: FGF23 as a regulator of phosphate metabolism and beyond

Cell Biology: Mechanistic FGF23 research revealed novel concepts of FGF receptor signaling

Biochemistry: Molecular crosstalk between FGF23 and klotho, from structure and binding to signal transduction

Pharmacology: FGF23 and its receptors as potential drug targets to treat or prevent diseases, such as CKD, heart failure or COPD

Basic Research: Cell culture and animal models as well as novel assays to study FGF23 production and effects

Nephrology: FGF23 as a biomarker and cause for CKD and associated pathologies

Internal Medicine: FGF23 as a biomarker and cause for various diseases involving the kidney, heart, lung and liver

Medical & VeterinaryBrances of medicineEndocrinologyDiabetes Publisher: Elsevier Science Publishing Co Inc Publication Date: 01/11/2020 ISBN-13: 9780128180365  Details: Type: Paperback Format: Books
Availability: Pre-order for despatch on publication. Pre-Order

Dr. Faul earned his PhD title at the Albert Einstein College of Medicine in the Bronx in 2005, and conducted his postdoctoral research training at the Mount Sinai School of Medicine in New York City. He currently is an Associate Professor in the Division of Nephrology within the Department of Medicine and in the Department of Cell, Developmental and Integrative Biology (CDIB) at UAB.) He is also a member of the Comprehensive Diabetes Center and Section of Cardio-Renal Physiology and Medicine. He focuses on circulating fibroblast growth factors and their pathological effects on the heart in the context of diabetes and chronic kidney disease. In collaborations with pharma industry, Dr. Faul analyzes beneficial cardiac effects of pharmacological blockers for fibroblast growth factor receptors in animal models with diabetes and kidney injury. Dr. Faul received research funding from the American Diabetes Association (ADA), the American Society of Nephrology (ASN), and American Heart Association (AHA), and the NephCure Foundation, as well as support from pharma industry. Dr. White studied the molecular genetics of metabolic bone diseases during an NIH-sponsored postdoctoral fellowship at the Indiana University School of Medicine (IUSM). He played an instrumental role in discovering the novel hormone FGF23 during this time, and since then his laboratory has been funded to study FGF23 and its co-receptor Klotho. Within the University, he is Director of the MMGE Division of Molecular Genetics and Gene Therapy and currently a member of the Indiana Center for Musculoskeletal Health (ICMH). Dr. Gutierrez is the Hilda B. Anderson Endowed Chair in Nephrology, Professor of Medicine and Epidemiology, Associate Director of the Division of Nephrology, and Deputy Director of the Center for Clinical and Translational Science at the University of Alabama at Birmingham (UAB). Dr. Gutierrez's research is focused on understanding pathophysiological mechanisms underlying disorders of phosphorus and vitamin D metabolism in health and in individuals with kidney disease. He has a special interest in delineating environmental and/or behavioral factors that may modulate these associations, particularly those related to health disparities, poverty and nutrition. To this end, his group conducts epidemiologic and patient-oriented studies investigating the impact of disturbances in phosphorus metabolism on kidney and cardiovascular health. He is funded by grants from the National Institutes of Health, the American Heart Association, and industry.

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