Enter your search into one or more of the boxes below:
You can refine your search by selecting from any of the options below:
Non-Mendelian Genetics in Humans
Foyalty 111

Non-Mendelian Genetics in Humans (Hardback)

Usually despatched within 3 weeks.


When rediscovered at the turn of the century, Mendel's laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendel's rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission.

In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectual heirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes-gonadal and somatic mosaicism, sex-linked

inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection-resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, and

their products. Thus the book presents a holistic view of human genetics.

In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism-the view that a person's phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypes cannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in their occurrence. Hence,

there are innate limits to genetic determinism. Although prediction of phenotype based on genotype will improve in the future as all of the human genes are identified, such predictions will always remain imprecise.

Medical & VeterinaryPre-clinical medicine: basic sciencesHuman reproduction, growth & developmentHuman growth & developmentMedical & VeterinaryPre-clinical medicine: basic sciencesMedical genetics Publisher: Oxford University Press Inc Publication Date: 01/05/1998 ISBN-13: 9780195068771  Details: Type: Hardback Format: Books
Availability: Usually despatched within 3 weeks. Add to Basket

Harry Ostrer, M.D., is Associate Professor of Pediatrics and Pathology and Director of the Human Genetics Program at New York University Medical Center. His current research is concentrated in the areas of genetic control of male sexual development, the genetic basis of cancer susceptibility, human population genetics, and assuring fairness in the use of genetic information.

More books by Harry Ostrer

Leave Review


Delivery Options

All delivery times quoted are the average, and cannot be guaranteed. These should be added to the availability message time, to determine when the goods will arrive. During checkout we will give you a cumulative estimated date for delivery.

Location 1st Book Each additional book Average Delivery Time
Free UK Standard Delivery on Orders Over £20 (2nd Class)     3-5 Days
UK Standard Delivery (2nd Class) £2.75 £0.00 3-5 Days
UK 1st Class Delivery £3.75 £0.00 1-2 Days
Click and Collect / 
Delivery to a Foyles Bookshop
Free Free From 2 hours - Individual item delivery times given at checkout
UK Courier £7.95 £0.00 1 Working Day
Western Europe**Airmail £9.00 £1.00 7-8 Days
Rest of World Airmail £12.50 £1.00 7-10 Days

** Includes Austria, Belgium, Denmark, France, Germany, Greece, Iceland, Irish Republic, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden and Switzerland.

Click and Collect is available for all our shops; collection times will vary depending on availability of items. Individual despatch times for each item will be given at checkout.

Delivery Help & FAQs

A Year of Books Subscription Packages 

Delivery is free for the UK. Western Europe costs £60 for each 12 month subscription package purchased. For the Rest of the World the cost is £100 for each package purchased. All delivery costs are charged in advance at time of purchase. For more information please visit the A Year of Books page.

Returns Information

If you are not completely satisfied with your purchase*, you may return it to us in its original condition with in 30 days of receiving your delivery or collection notification email for a refund. Except for damaged items or delivery issues the cost of return postage is borne by the buyer. Your statutory rights are not affected.

* For Exclusions and terms on damaged or delivery issues see Returns Help & FAQs

You might also like

And Bloom: The Art of Aging...
Denise Boomkens
The Menopause Manifesto
Dr. Jennifer Gunter
Frankie Bridge
Lifespan: Why We Age - and Why We...
Dr David A. Sinclair
© W&G Foyle Ltd
Foyles uses cookies to help ensure your experience on our site is the best possible. Click here if you’d like to find out more about the types of cookies we use.
Accept and Close