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PEGylated Protein Drugs: Basic Science and Clinical Applications
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PEGylated Protein Drugs: Basic Science and Clinical Applications (Hardback)

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Synopsis

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Medical & VeterinaryBrances of medicineDiseases & disordersImmunologyMedical & VeterinaryBrances of medicinePharmacology Publisher: Birkhauser Verlag AG Publication Date: 18/09/2009 ISBN-13: 9783764386788  Details: Type: Hardback Format: Books
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