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Receptor - Based Drug Design
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Receptor - Based Drug Design (Hardback)

£150.00
£135.00
10%
Usually despatched within 3 weeks.

Synopsis

Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.

Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors-providing the pharmacological information needed to solve treatment problems and facilitate the drug design process!

Demonstrating the achievements of the receptor-based approach in therapeutics and indicating future directions, Receptor-Based Drug Design

introduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptors



shows how to assess agonist concentration-effect curve data



discusses radioligand binding assays



presents new in vitro multiarray assays for G-protein-coupled receptors



explains the use of individual second messenger signaling responses in analyzing drug-receptor interactions



examines the role of electrophysiology in finding new drugs and drug targets



describes selectively acting b-adrenoceptor agonists and glucocorticoid steroids for asthma treatment



outlines the rationale for using angiotensin receptor antagonists



and more!

Written by over 25 international authorities and containing nearly 1200 bibliographic citations, Receptor-Based Drug Design is a practical resource for pharmacologists, pharmacists, and pharmaceutical scientists; organic and medicinal chemists and biochemists; molecular biologists; biomedical researchers; and upper-level undergraduate and graduate students in these disciplines.

TechnicalIndustrial chemistry & manufacturing technologiesIndustrial chemistryPharmaceutical technology Publisher: Taylor & Francis Inc Publication Date: 10/04/1998 ISBN-13: 9780824701628  Details: Type: Hardback Format: Books
Availability: Usually despatched within 3 weeks. Add to Basket

Leff Paul

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