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Domino Reactions in Drug Discovery
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Domino Reactions in Drug Discovery (Paperback)

£185.00
Awaiting publication

Synopsis

Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors.

Science & MathematicsChemistryOrganic chemistryTechnicalIndustrial chemistry & manufacturing technologiesIndustrial chemistryPharmaceutical technology Publisher: Elsevier Science Publishing Co Inc Publication Date: 01/04/2023 ISBN-13: 9780128193747  Details: Type: Paperback Format: Books
Availability: Awaiting publication Pre-Order

Dr. Shanta Bhar is a medicinal and computational scientist with 13 years of postdoctoral experience in designing and synthesizing new chemical entities and developing investigational new drug applications (NDAs) for diabetes, cancer, and inflammation with emphasis on pre-clinical small molecule drug discovery. Dr. Bhar specializes in domino reactions, computer-aided drug design (CADD), structure-based drug design (SBDD), and ligand-based drug design (LBDD), spanning the therapeutic areas of cancer, diabetes, and dengue. She works to aid therapeutic development by formulating concise, efficient and scalable synthetic strategies that integrate the versatility of domino reactions to generate complex derivatized scaffolds thus streamlining the process and economic viability of a drug from conception to approval. Dr. Bhar's current research is directed towards the synthesis of members of the epothilone family, a newer class of microtubule inhibitors, which is involved in the growth of solid tumors and VEGF [vascular endothelial growth factor] inhibitors, that affect the process of angiogenesis by reducing tumor size and tendency to metastasize. In both pharma research and academic pursuits, Dr. Bhar has laid out the roadmap and designed potential drug candidates. She has worked on lead optimization and design of retrosynthetic strategy, and has been exploring avenues to scale down complex syntheses or synthesis of complex drugs including chiral drugs. These include established pharmaceuticals, pre-clinical candidates, promising potential NCEs, and agrochemicals involving efficient utilization of Domino Reactions.

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