Combinatorial Chemistry

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This text explains the origins of combinatorial chemistry and puts the many diverse library methods into context. It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This book describes the beneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques should be a valuable text for final year undergraduates, postgraduates, academics and industrialists in chemistry, bio-organic chemistry, medicinal chemistry and drug discovery. It should provide an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.